Endocrine Abstracts

Introduction: Testosterone deficiency is associated with an increased risk of type-2 diabetes (T2D) in men. Physiological testosterone replacement (TRT) improves insulin resistance and glycaemic control in hypogonadal men with T2D. The mechanisms underlying these actions remain unknown, but may be due in part to an effect on the liver as a major metabolic organ involved in glucose regulation. We have previously shown in testicular feminised mice, which have low testosterone le...

Introduction: There is a strong association between testosterone deficiency and the incidence of type 2 diabetes (T2D) in men. Physiological testosterone replacement (TRT) improves insulin resistance and glycaemic control in hypogonadal men. The mechanism by which testosterone mediates these beneficial actions are unknown but may be due to an effect on major metabolically active tissues such as liver and muscle. This study investigates the expression of key regulatory targets ...

Testosterone deficiency increases risk for cardiovascular disease (CVD) and type 2 diabetes. Testosterone replacement (TRT) improves insulin resistance, glycaemic control and cholesterol in hypogonadal men. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism. LXR agonists protect against atherosclerosis but cause hepatic steatosis. We have previously shown that TRT protects against hepatic steatosis and atherosclerosis in high-fat diet-fed...

Objectives: Testosterone deficiency is common in obese men with type 2 diabetes. Testosterone replacement therapy (TRT) improves insulin resistance, glycaemic control and cholesterol in hypogonadal men, and TRT reduces body fat mass. Adipose tissue plays a major role in glucose homeostasis and insulin sensitivity through the regulation of lipid and glucose metabolism. There are functional differences between subcutaneous and visceral adipose tissue. This study investigates the...

Objectives: A clinical feature of insulin resistance is the development of fatty liver (hepatic steatosis). Testosterone deficiency is common in men with type-2 diabetes and is associated with insulin resistance. The testicular feminised mouse (Tfm) exhibits a non-functional androgen receptor (AR) and low circulating testosterone. We have previously shown that a high-cholesterol diet promotes hepatic steatosis in Tfm mice, and testosterone replacement therapy (TRT) attenuates ...

Objectives: Symptomatic hypogonadism is common in obese men with type-2 diabetes (T2DM) and metabolic syndrome (MetS), and is now an independent risk factor for cardiovascular disease. Testosterone replacement therapy (TRT) improves cholesterol metabolism in hypogonadal men with T2DM and/or MetS. We have previously shown that a non-functional androgen receptor (AR) and low levels of circulating testosterone in the testicular feminised (Tfm) mouse is associated with elevated ch...